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Current news items from Neotherix are listed below. See the Archived News page for older articles.

22/06/17 PhotoTherix™ project update at Medical Technologies IKC and Regener8 Annual Conference 2017

Richard Baker, Research Assistant at the Centre for Skin Sciences, University of Bradford, will be presenting a poster titled "Evaluation of the novel PhotoTherix™ scaffold system for treating infected wounds". The poster provides an update on progress made in the project of the same name, describing the interaction of PhotoTherix with human and bacterial cells relevant to skin wounds.

The project is funded by the Medical Technologies Innovation and Knowledge Centre (IKC), and aims to generate proof-of-concept data for the repositioning of the PhotoTherix technology for skin wound applications. The Centre for Skin Sciences, University of Bradford leads the project consortium with Neotherix as the industrial partner. The consortium is further supported by the WoundTec Health Technology Co-operative as clinical partner with commercial support provided by Medilink Yorkshire & Humber.

Please see our previous news article on the PhotoTherix project for more details of the project.

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22/06/17 Neotherix presenting at Medical Technologies IKC and Regener8 Annual Conference 2017

Dr Lorenzo Pio Serino, Biomaterials Scientist at Neotherix, will be presenting at the Medical Technologies IKC and Regener8 Annual Conference 2017. This joint conference will take place on Friday 23 June 2017 in Leeds and is focussed on best practice in translating regenerative devices.

Lorenzo Pio will be co-presenting "Tissue repair capacity of a prototype antimicrobial-releasing scaffold: dental applications" with Dr Giuseppe Tronci, Lecturer in Healthcare Materials at the University of Leeds. In addition to summarising work undertaken to demonstrate proof-of-concept for dental applications for our PhotoTherix™ tissue scaffold technology, the presentation will describe recent work evaluating the interaction of relevant human and bacterial cells with photosensitiser-loaded scaffolds.

Please see the conference web page Link to external web site for more information.

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19/06/17 Neotherix on the programme for UK Society for Biomaterials 2017

Dr Peter Iddon will give a talk at the forthcoming UK Society for Biomaterials meeting at Loughborough University. "Electrospun bioresorbable tissue repair scaffolds: travelling the pathway from laboratory to clinic" will form part of the session on 3D materials on Day 2 (Wednesday 21 June). Peter will cover the concepts underlying the electrospinning process and the particular applications to which Neotherix have deployed this. These include clinical use for acute wound repair (EktoTherix™), delivery of antimicrobial activity to infected wound sites (PhotoTherix™) and in vitro use for tissue and disease modelling. The full programme can be viewed on the event’s web page Link to external web site.

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24/04/17 Full Sector Panel announced for Leeds City Region MedTech event

The full Sector Panel has now been announced for the panel discussion taking place at the The Future of Med Tech in the Leeds City Region: Translate in Action event in Leeds on Tuesday 25 April 2017. SMEs are a vital component of the MedTech sector and, as announced in our previous news item, we are very pleased that Neotherix has been invited to give the views from this part of the industry mix.

See the event’s web page Link to external web site for more information.

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20/04/17 Neotherix announced as part of the Sector Panel at Leeds City Region MedTech event

Neotherix' Development Manager, Dr Peter Iddon has been invited to sit on the panel for a discussion on current and future opportunities for economic growth in the Medical Technology sector in the Leeds City Region. The panel discussion will take place at The Future of Med Tech in the Leeds City Region: Translate in Action, a one day event taking place on Tuesday 25 April 2017 and organised by Translate, a partnership of universities in the Leeds City Region with world-class capabilities in the development of new medical technologies.

Neotherix' participation in the panel will ensure that the perspectives of micro-SMEs are included in the debate, which is essential in bringing a balanced view to the development of a vision for the role of the Medical Technology sector in the Leeds City Region.

See the event’s web page Link to external web site for more information.

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23/03/17 Neotherix participates in Leeds City Region's Science and Innovation Audit

Neotherix' Development Manager, Dr Peter Iddon has been interviewed as part of the Leeds City Region's Science and Innovation Audit (SIA). This SIA - awarded by BEIS to a University of Leeds-led consortium - focuses on the UK's strengths in Medical Technology. The Leeds City Region - in which Neotherix is located - has a "world-leading concentration of excellence in research and innovation in medical technology" according to Professor John Fisher who is leading the SIA.

Commenting on Neotherix' participation in the SIA, Peter said "we welcome the recognition of the region's contribution to medical technology innovation, and look forward to the SIA providing evidence of this sector's existing strengths and how these can be built upon to enable its full potential to be reached. We're pleased to have an input into this process".

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21/02/17 EktoTherix™: First in Man clinical investigation recruitment completed

Neotherix are pleased to announce that the First in Man clinical investigation of EktoTherix™ Tissue Repair Scaffold has recruited twelve participants. Recruitment is now closed and the clinical data collected from all participants are undergoing 100% source data verification prior to statistical analysis.

This initial safety study has assessed EktoTherix for the treatment of full-thickness, dermatologic wounds created by the surgical removal of non-melanoma skin cancers. Study outcomes following the application of EktoTherix Tissue Repair Scaffold to these excisional wounds were recorded. The scaffold is expected to promote repair of the wound by the patients' own cells, enhancing healing and improving quality of repair. EktoTherix is designed to be completely resorbed by the body during the healing process so there is no need for removal when the wound has healed.

The primary objective of this current study was to assess the safety of EktoTherix in humans with a secondary objective to evaluate its clinical performance. Our hypothesis is that use of EktoTherix will increase incidence of complete and problem-free healing and result in an overall better cosmetic result (cosmesis) of the healed wound.

For more information on the study see the EktoTherix study record on ClinicalTrials.gov Link to external web site.

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06/02/17 Medical Technologies IKC funding for new PhotoTherix™ project

A consortium led by the Centre for Skin Sciences, University of Bradford with Neotherix as the industrial partner has won a Proof of Concept grant to evaluate PhotoTherix™ as a skin wound regenerative scaffold. The £119k grant from the Medical Technologies Innovation and Knowledge Centre (IKC), will allow the project team to continue the work on photodynamic therapy (PDT) delivered by Neotherix’ PhotoTherix™ tissue scaffold technology.

The project, led by Professor Des Tobin from the University of Bradford, started work in January and aims to develop an enhanced bioresorbable scaffold functionalised with a photo-sensitising agent to provide a 3D substratum for wound healing whilst delivering broad spectrum antimicrobial activity via PDT. Testing will include activity of PhotoTherix prototypes against common wound pathogens when activated by light. The project will benefit from the collaboration with the clinical partner WoundTec Health Technology Co-operative and will also receive commercial support from Medilink Yorkshire & Humber. It will also complement existing projects to develop the technology for dental applications in collaboration with the University of Leeds.

Link to the Medical Technologies IKC Link to external web site and to our PhotoTherix™ development partners the Centre for Skin Sciences Link to external web site, WoundTec HTC Link to external web site and Medilink Yorkshire & Humber Link to external web site.

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11/11/16 Neotherix to exhibit at Venturefest Yorkshire 2016

Neotherix will be exhibiting at Venturefest Yorkshire 2016, a one day exhibition of Yorkshire's most inspiring science, technology and knowledge companies, on 16 November 2016 at York Racecourse. The event is designed to nurture business growth in the region by showcasing entrepreneurs to potential investors and helping innovators develop their ideas.

Mike Raxworthy (Neotherix' CEO) will be chairing the Bioscience session at 15:00 in the afternoon. The session is a showcase of Yorkshire life sciences and includes several excellent speakers who will deliver presentations covering robotic surgery, stem cells, smart orthopaedics and next generation therapeutics.

Please come and visit us at stand B11 in the Bio-Synergy Zone on the second floor.

See the Venturefest Yorkshire website Link to external web site for more information, including more details of the seminar programme.

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11/10/16 New tendon repair review

A collaboration involving UEA, Neotherix and the University of Leeds has published a review on "A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration". The review by Walden et al (Tissue Engineering Part B: Reviews. September 2016, ahead of print. doi:10.1089/ten.teb.2016.0181) can be found at online.liebertpub.com/doi/abs/10.1089/ten.TEB.2016.0181 Link to external web site. The review considers the means of stimulating the body's own repair system to produce de novo tissue through the use of cells, proteins, and genes delivered by a biomaterial scaffold.

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26/09/16 Neotherix selected to pitch at 2016 BioCap life science and investment conference

We are pleased to announce that Neotherix has been selected to give a company pitch at the annual BioCap conference on Thursday 29 September 2016 at the Alderley Park Conference Centre in Cheshire. Now in its fifth year, the specialist life science and investment conference will bring together investors, life science companies seeking finance, and those with a track record of raising finance.

Dr Mike Raxworthy, the company's founder and CEO, will be presenting on Neotherix to an invited audience of investors. Mike's presentation will cover all Neotherix' current regenerative tissue scaffold projects before concluding with a closer look at recent clinical and manufacturing progress made with EktoTherix™.

Please see the BioCap conference web page Link to external web site for more information.

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16/09/16 Mike Raxworthy to chair seminar at Venturefest Yorkshire 2016

Mike Raxworthy has been invited to organise and chair the Bioscience seminar session at Venturefest Yorkshire 2016. Bioscience will be one of the seminars taking place within the Bio-Synergy zone at the event. The seminar programme is currently being finalised and the speaker line-up will be announced soon.

Venturefest Yorkshire "is a one day festival with a clear remit to nurture business growth in the region - by helping innovators develop their ideas and helping entrepreneurs get investment". It takes place at York Racecourse on 16 November 2016. Full details are on the Venturefest Yorkshire website Link to external web site.

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14/09/16 New research paper published with Neotherix author

Researchers at UEA have had a paper published in the European Polymer Journal on the use of polymers made by a novel synthetic route to complex with DNA (polyplexation). Star-shaped PDMAEA polymers were found to perform better in polyplexation than linear polymer variants and to be equally non-cytotoxic at low (10kDa) molar mass. The findings indicate that star-shaped PDMAEA polymers may be effective as non-viral gene delivery vectors.

Authors include Dr Aram Saeed and members of his research group (Xin Liao, Noelia Falcon and Grace Walden – whose PhD studies are supported by an EPSRC ICASE grant for which Mike Raxworthy is the industrial supervisor. Grace’s other supervisors Simon Donell and Graham Riley are also authors on the paper.

The article in press is X. Liao et al, A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines; Eur Polym J (2016) Link to external web site.

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31/08/16 EktoTherix™: Additional site now recruiting patients to clinical investigation

Neotherix are pleased to announce the addition of a third site to the First in Man clinical investigation of EktoTherix™ Tissue Repair Scaffold. James Cook University Hospital (South Tees Hospitals NHS Foundation Trust) commenced participation on 25 July, and the clinical team there have already recruited one additional patient to the study.

The addition of James Cook University Hospital supports the work of the two original sites, York Hospital and Scarborough Hospital (both York Teaching Hospital NHS Foundation Trust), and is expected to significantly enhance the rate of patient recruitment to the study.

As reported previously, this initial safety study assesses EktoTherix for the treatment of full-thickness, dermatologic wounds created by the surgical removal of non-melanoma skin cancers. Study outcomes following the application of EktoTherix Tissue Repair Scaffold to wounds resulting from these surgical excisions are recorded. The scaffold is expected to promote repair of the wound by the patients' own cells, enhancing healing and improving quality of repair. The tissue scaffold is designed to be completely resorbed by the body during the healing process so that there is no need for removal when the wound has healed.

Although the primary objective is to assess the safety of EktoTherix in humans, a secondary objective is to evaluate its clinical performance. The ability of EktoTherix to increase incidence of complete healing and result in an overall better cosmetic result (cosmesis) of the healed wound will be monitored.

For more information on the study see the EktoTherix study record on ClinicalTrials.gov Link to external web site.

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22/04/16 Neotherix achieves ISO 13485 certification milestone

We are delighted to announce that Neotherix has achieved the milestone of ISO 13485 certification – the standard specifying comprehensive requirements for quality management systems used by medical device manufacturers and distributors.

We are certified to both ISO 13485:2003 and EN ISO 13485:2012 for the "design and manufacture of sterile bioresorbable wound repair products." The award of this certification (by the Notified Body SGS) demonstrates Neotherix' commitment to high standards of quality. SGS is accredited by UKAS to assess whether manufacturers and their medical devices meet the requirements set out in European legislation.

Commenting on the accomplishment, CEO Prof. Mike Raxworthy said "Neotherix Ltd is committed to the highest level of quality in all our operations, including the development, manufacture, sale and support of our products and services. Our overall objective is to provide high quality medical technology and regenerative medicine products and services that satisfy customer needs. Attaining the high standards demanded by ISO 13485 certification is a very significant milestone in our path towards eventually gaining a CE marking for our lead product EktoTherix™, and I'm very proud of this achievement."

Independent verification of our certification status can be found online through SGS's Certified Client Directory Link to external web site.

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15/04/16 Neotherix selected to join Hiscox Business Club

We are pleased to announce that Neotherix is one of 30 local small businesses and entrepreneurs chosen to join the recently launched Hiscox Business Club, operating within Hiscox' new landmark office in York. The Club is an initiative of Hiscox in collaboration with York St John University, Make it York and the York, North Yorkshire & East Riding Local Enterprise Partnership. Membership benefits extend beyond the use of state-of-the-art office facilities and meeting/video-conferencing rooms and provides the opportunity to work with other small companies in York, bringing our experience, connections and insights into innovation and technology translation. We are looking forward to taking part in events, networking and insight sessions - and the roof garden (with spectacular views of York Minster) would be a fantastic venue for the launch of EktoTherix™!

See the Hiscox Business Club page Link to external web site for more information on the club and the Hiscox blog Link to external web site for more information on its members,

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10/03/16 Neotherix included in Super North supplement for The Times

Neotherix projects and other activities were covered in a recent Super North Life Sciences supplement for The Times, published on 23 February 2016. The Bionow awards for 2015 included the RegeniTherix™ Wound Theranostic System as the winner of the Project of the Year Award (for which Neotherix is a member of a consortium led by NPL and including SensaPharm, Complement Genomics and Leeds Teaching Hospitals). The potential of this product to improve the treatment of chronic wounds was noted and was that of Neotherix' lead product EktoTherix™ - currently undergoing clinical investigation - for the repair of acute (surgical) wounds. Neotherix CEO Mike Raxworthy's contribution to the Super North Forum on the strength of the life sciences sector in the North of England was also recognised.

Please see the attached Super North supplement (copyright ©2016 Super North).

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04/02/16 Mike Raxworthy appointed to RAEng Visiting Professorship at University of Leeds

Neotherix CEO, Mike Raxworthy has recently been appointed as a Royal Academy of Engineering (RAEng) Visiting Professor in Medical Technology Innovation and Translation at the University of Leeds.

As Visiting Professor, Mike will work closely with academic colleagues to embed innovation into undergraduate teaching in Medical Engineering. Students in this area of study currently have little exposure to innovation which is inconsistent with the idea that the UK economy requires innovation-competent engineers and scientists to develop ground-breaking medical technology products. This Visiting Professorship will also enhance student understanding of the steps required to translate an idea from concept to marketed product and, in so doing, improve the employability skills of engineering graduates.

In addition, Mike's extensive network will allow the University of Leeds to strengthen external partnerships with the medical device/medical technology industry and to broaden both the group of industry contacts and the number and type of activities that the students participate in. Mike will co-ordinate a programme in which industry experts deliver face-to-face teaching and offer inspiration through their knowledge and experience, allowing the development of an exciting innovation and translation curriculum.

The RAEng Visiting Professorship recognises the value that companies such as Neotherix bring to the innovation and translation processes and seeks to use some of this experience and know-how to benefit undergraduate and postgraduate learning in medical technology. Mike will combine this with his role as Operations Director of Regener8 which will continue to run alongside his Neotherix responsibilities.

The award will also allow Mike to extend his study of the work of regenerative medicine/medical technology translation centres to look at both European and developing world centres.

Please see the RAEng web pages introducing the Visiting Professors initiative Link to external web site and listing current Visiting Professorship awardees Link to external web site for more information.

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02/12/15 Mike Raxworthy appointed External Examiner

Neotherix CEO, Dr Mike Raxworthy has been appointed an External Examiner by Swansea University. He will attend the viva and examine a PhD thesis on "Products of Antimicrobial Nanofibrous Non-Wovens using the Electrospinning Technique."

Link to the University of Swansea’s Nanotechnology page Link to external web site.

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27/11/15 RegeniTherix™ Wound Theranostic System wins Bionow Project of the Year Award

We are proud to announce that RegeniTherix - a system for the point of care testing and treatment of chronic, non-healing wounds such as diabetic foot ulcers and venous leg ulcers - won the Project of the Year category at yesterday's Bionow Awards.

The RegeniTherix consortium is National Physical Laboratory (project leader), Neotherix, Leeds Teaching Hospitals NHS Trust, SensaPharm and Complement Genomics. The project is funded by the National Institute for Health Research (NIHR) Invention for Innovation (i4i) programme.

See the Bionow announcement Link to external web site for details of the award winners.

For more information on the RegeniTherix project and Bionow awards please see our previous news article.

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24/11/15 RegeniTherix™ Wound Theranostic System short-listed for Bionow Project of the Year Award

RegeniTherix - a system for the point of care testing and treatment of chronic, non-healing wounds such as diabetic foot ulcers and venous leg ulcers - has been shortlisted in the Project of the Year category in the Bionow Awards, which recognise the very best life sciences companies and innovations in the north of England.

The RegeniTherix system consists of a bioresorbable 'scaffold' to encourage growth of the patient's own cells into the wound space to begin repair and a hydrogel to enable the collection and sampling of biomarkers produced by these new cells. The biomarkers are measured using a hand-held reader device and provide clinicians with information on the healing or non-healing status of the wound. Knowing whether certain barriers to healing are present, such as excessive inflammation, high levels of degradative enzymes, poor tissue perfusion or infection, allows clinicians to select the most appropriate wound treatments for different patient groups. In this way, RegeniTherix is both a therapeutic - promoting chronic wound healing - and a diagnostic device ("theranostic").

The RegeniTherix system has been developed by a consortium led by the National Physical Laboratory (NPL) and involving York-based Neotherix, Leeds Teaching Hospitals NHS Trust and the Durham-based companies SensaPharm and Complement Genomics. The project is funded by the National Institute for Health Research (NIHR) Invention for Innovation (i4i) programme.

The cost of wounds to the NHS has been estimated to be more than £3 billion per year and to consume around 3% of the NHS's entire budget. NICE estimates that the cost of a wound to the NHS is £4,750 per patient and a range of £4,850-£7,500 per patient has been estimated for Europe as a whole. With an ageing population and the rising incidence of chronic diseases - both of which increase the incidence of chronic wounds - controlling and reducing the amount spent on treating wounds is of vital importance. A saving of 5% (achieved through improved healing, earlier patient discharge and fewer "wasted" dressings) will take around £200m pa off the NHS's budget and this is the initial target for RegeniTherix.

The Bionow Project of the Year Award criteria include the need to demonstrate the use of innovative approaches to develop biomedical products and will be awarded on the basis of the quality of the project and the degree of innovation. The winners of this and other awards for 2015 will be announced at the Bionow Annual Awards Dinner taking place on Thursday 26 November at the Mere Golf Resort and Spa, Cheshire at which the RegeniTherix consortium will be represented by Dr Mike Raxworthy from Neotherix.

For more information please see the Bionow Annual Awards Dinner web page Link to external web site.

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12/10/15 Neotherix presenting at World Conference on Regenerative Medicine 2015

Neotherix CEO Dr Mike Raxworthy will be speaking at the World Conference on Regenerative Medicine 2015, to be held in Leipzig, Germany on 21-23 October. The interdisciplinary conference, which is typically attended by around 1,000 delegates, covers a broad range of regenerative medicine topics including biomaterials and tissue interaction, cell therapies, models of regeneration, tissue engineering and regulatory affairs.

Mike's presentation will be given during the Muscle, Skin, and Soft Tissue Regeneration session on Day 3 of the conference, 23 October, and will focus on the translation of our EktoTherix™ tissue repair scaffold "from test rig to clinic". The presentation will describe the pathway travelled and the learning gained by Neotherix during the development of EktoTherix. The product is currently being evaluated in a First in Man clinical safety study which is, to the best of our knowledge, the first full clinical investigation of a bioresorbable electrospun scaffold.

For more information, please see the World Conference on Regenerative Medicine web page Link to external web site.

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22/09/15 Neotherix selected to pitch at 2015 BioCap conference

We are delighted to announce that Neotherix has been selected to give a company pitch at the annual BioCap conference on Wednesday 30 September 2015 at the Alderley Park Conference Centre in Cheshire. Now in its fourth year, the conference will bring together investors, life science companies seeking finance, and those with a track record of raising finance. BioCap is reported to be the only life science and investment conference in the North of England.

Dr Mike Raxworthy, the company's founder and CEO, will be presenting on Neotherix to an invited audience of investors. Mike's presentation will focus mainly on EktoTherix™ regenerative tissue scaffold for acute wound repair but will also cover wider opportunities arising from EktoTherix and from pipeline projects.

Please see the BioCap conference web page Link to external web site for more information.

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03/09/15 Neotherix presenting at Regener8 Annual Conference as part of MEIbioeng15

Dr Peter Iddon, Development Manager at Neotherix, will be presenting at the Regener8 Annual Conference 2015, which is one track of the MEIbioeng15 Conference taking place at the University of Leeds on Monday 7 and Tuesday 8 September 2015. Peter's presentation, Translation of EktoTherix™, a synthetic acellular scaffold for wound regeneration: learning by doing, will take place during The Delivery of Regenerative Medicine track on the second day. It will focus on the learning gained from assembling the evidence required in order to take our lead scaffold technology, EktoTherix™, to its first evaluation in a clinical investigation.

Please see the Regener8 Annual Conference web page Link to external web site and MEIbioeng15 web site Link to external web site for more information.

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10/06/15 Neotherix in new collaboration with the School of Dentistry, University of Leeds

Neotherix is pleased to announce the start of a new collaboration with the School of Dentistry, University of Leeds. This continues our work on photodynamic therapy delivered by our PhotoTherix™ tissue scaffold technology. Research work will be conducted by Malaysian PhD student Rina Haryani bt. Osman Basah and supervised by Dr Simon Wood and Professor Xuebin Yang from the School of Dentistry and Dr Mike Raxworthy from Neotherix. We welcome Rina to the UK and to the project!

Link to the School of Dentistry at the University of Leeds Link to external web site.

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08/06/15 New publication on the use of Neotherix scaffold technology to create 3D tissue models

Dr Mike Raxworthy, Dr Lorenzo Pio Serino and Dr Peter Iddon are co-authors of a paper just published online in Biofabrication. The paper, "A three dimensional model of primary bovine endometrium using an electrospun scaffold", describes collaborative work carried out by Dr Siân MacKintosh of Swansea University using Neotherix electrospun scaffold technology to create a functional 3D model of bovine endometrium. Stromal and epithelial cells were grown on the Neotherix scaffold, resulting in a layered arrangement similar to native endometrium. Analysis confirmed the appropriate expression of key biomarkers for this tissue type.

This 3D model could be used for the study of the pathophysiology of this commercially important tissue. In cattle the endometrium plays key roles in reproduction, and diseases affecting this tissue are a large burden to the farming industry. For example, according to senior author Professor Martin Sheldon Link to external web site, infection of the uterus following calving is estimated to cost the EU farming industry €1.4bn annually due to the cost of treatment, infertility and reduced milk yields.

This approach could be used to create other species-specific 3D models of important tissue types, including human tissue, and these results are further evidence of the versatility of electrospun scaffolds in the construction of in vitro disease and tissue models.

For more detail please see the published paper MacKintosh, SB, Serino, LP, Iddon, PD, Brown, R, Conlan, RS, Wright, CJ, Maffeis, TGG, Raxworthy, MJ, and Sheldon, IM, Biofabrication 2015, 7:025010 Link to external web site. A pre-print version is also available here Link to external web site.

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03/06/15 EktoTherix™: First Patients Recruited

Neotherix are pleased to announce a major milestone in the development of EktoTherix™ Tissue Repair Scaffold: a First in Man clinical investigation is currently open for recruitment and the first patients have been recruited. This initial safety study will assess EktoTherix in the treatment of full-thickness, dermatologic wounds created by the surgical removal of non-melanoma skin cancers. Up to fifteen patients will be recruited across two sites in the York Teaching Hospital NHS Foundation Trust: The York Hospital and Scarborough Hospital.

The Investigation will assess outcomes following the application of EktoTherix Tissue Repair Scaffold to wounds resulting from these surgical excisions. The scaffold is expected to help the patients' own cells repair the wound, enhancing healing and improving quality of repair. The tissue scaffold is designed to be completely absorbed by the body during the healing process so that there is no need to remove it when the wound is healed.

Although the primary objective is to assess the safety of EktoTherix in humans, a secondary objective is to evaluate its clinical performance. Our hypothesis is that use of EktoTherix will increase incidence of complete healing and result in an overall better cosmetic result (cosmesis) of the healed wound.

For more information on the study see the EktoTherix study record on ClinicalTrials.gov Link to external web site.

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12/05/15 Neotherix presenting at Regener8/Science City York Technology Digests - Regenerative Scaffolds

Dr Peter Iddon, Development Manager at Neotherix, will be presenting at Regener8/Science City York Technology Digests - Regenerative Scaffolds, to be held at the Department of Biology at the University of York on Wednesday 13 May 2015. Peter's presentation, Synthetic Bioresorbable Scaffolds: From Test Rig to Clinic will focus on the pathway our lead scaffold technology, EktoTherix™, has taken from its early development stages to its first evaluation in a clinical investigation.

Please see the event web page Link to external web site for more information.

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17/04/15 Neotherix attending 2015 BioSynergy Conference

Neotherix CEO Dr Mike Raxworthy will be presenting a poster titled "An Antimicrobial-Releasing Tissue Scaffold for the Repair of Oral Surgical Sites and Prevention of Graft Loss due to Infection" at the 2015 BioSynergy Conference, to be held on Tuesday 21 April at the National Agri-Food Innovation Campus in York. The one day event, on "Overcoming Barriers", will be co-hosted by Bionow and Science City York, and will focus on helping the life sciences community connect with potential partners.

Please see the BioSynergy event page Link to external web site for more information.

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04/03/15 Super Cells exhibition launch event

Dr Mike Raxworthy will be presenting at the launch event for the interactive exhibition Super Cells, to be held at the Centre for Life in Newcastle on Thursday 5 March 2015. Mike's presentation will consider 'The Power of Cells' from an industry point of view. Other talks will cover the clinical perspective (from Prof Jim Shaw, Newcastle University) and that of the Cell Therapy Catapult (from CEO Keith Thompson).

The Super Cells exhibition is being held at the Centre for Life from 28 February to 19 April 2015. It explores what stem cells are, how they live and their potential uses in medicine.

To enquire about attending the launch event please email supercells@ct.catapult.org.uk. Booking is not required to attend the Super Cells exhibition itself.

Please see the Super Cells web page Link to external web site for more information.

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11/02/15 UEA Industrial CASE project undergoes first interim review

Mike Raxworthy visited the University of East Anglia on 9 February to meet with academic supervisors Dr Aram Saeed and Dr Graham Riley, clinical supervisor Professor Simon Donell and the PhD student working on the project, Grace Walden. Plans for the development of a bioresorbable microparticulate approach to tendon repair were reviewed and approved. Neotherix is the industry sponsor for this iCASE project (see news item of 04/06/14) with Dr Raxworthy the industrial supervisor.

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09/02/15 New publication from Neotherix scientist

Dr Lorenzo Pio Serino, Biomaterials Scientist at Neotherix, is a co-author of a paper just published in Materials Science and Engineering C (Materials for Biological Applications). The paper, "Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering" describes collaborative work carried out by Lorenzo Pio while seconded by Neotherix to the University of Nottingham to learn about PLGA hydrogel technology.

The paper describes a new approach to modifying the rate of protein release from poly(DL-lactic acid-co-glycolic acid) (PLGA) microparticles. Blending the PLGA with triblock copolymers of PLGA and poly(ethylene glycol) (PEG) allowed the rate of release of a model protein, lysozyme, to be 'pre-programmed' or pre-selected. This approach could be used to create microparticle-based tissue engineering constructs with pre-programmed release properties. Neotherix are now applying some of the broad concepts explored during this secondment to their i4i-funded RegeniTherix project.

Please see Qodratnama, R, Serino, LP, Cox, HC, Qutachi, O and White, LJ Materials Science and Engineering C 2015, 47:230-236 Link to external web site for more information.

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19/12/14 Neotherix becomes Bionow member

Neotherix is pleased to announce that it has become a member of Bionow. Commenting on joining Bionow, CEO Mike Raxworthy said, "We are delighted now to be a Bionow member and take our place alongside other innovative life science businesses in this network. We are looking forward to bringing our technology skills into the biomedical cluster that Bionow is supporting in the North of England". Bionow offers a range of specialist business support products and services that can be tailored to the specific stage of development of its members.

Please see the Bionow web site Link to external web site for more information.

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21/11/14 Year in Industry Intern joins Neotherix team

We are delighted to welcome Alexej Vrublevskis to Neotherix as a Year in Industry Intern, who started with us in September. He has just completed his second year of a BSc Biochemistry degree at the University of York, and will be supporting the team on our existing projects to commercialise bioresorbable tissue regeneration scaffolds. The addition of Alexej will also allow us to explore new project opportunities.

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25/09/14 Neotherix is a Medipex NHS Innovation Awards 2014 Finalist

Medipex and Y&H AHSN NHS Innovation Awards and Showcase 2014 logo

Neotherix is pleased to announce that we are a Medipex NHS Innovation Awards 2014 Finalist. These awards are given to individuals, teams and companies working for or with the NHS in the Yorkshire and Humber region, whose ideas or inventions have, or could lead to, improvement in the patient experience.

One of five finalists in the Medical Devices & Diagnostics category, Neotherix will be attending the Medipex Innovation Awards and Showcase on 9 October 2014, which is being held in partnership with the Yorkshire and Humber Academic Health Science Network. The other four award categories are GP and Primary Care, Secondary Care, Mental Health & Wellbeing and Software & Telehealth.

Please see the Medipex NHS Innovation Awards 2014 web page Link to external web site for more information.

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16/09/14 Neotherix attending the Regener8 Annual Conference 2014

Neotherix will be attending the Regener8 Annual Conference 2014 "The Pathway to Innovation for Regenerative Therapies" on 17 September 2014. The one day meeting, to be held at the University of Leeds, will focus on the translation and commercialisation of regenerative therapies and is an opportunity to network with industrial, clinical and academic members of the regenerative medicine community.

In addition to industry-leading keynote speakers there will be a showcase of Regener8-funded projects (including a presentation by Professor David Watts on "Polymeric scaffolds functionalised for periodontal repair" – to which Neotherix is a partner).

Please see the Regener8 Annual Conference 2014 web page Link to external web site for more information.

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22/08/14 Congratulations to Neotherix-supported CASE student

Neotherix are very pleased to be able to congratulate Dr Brendan Robb on the successful completion of his PhD viva on 24 July 2014, for which his external examiner was Dr Asa Barber from the School of Engineering and Materials Science at Queen Mary University of London.

Brendan’s thesis, "Processing novel electrospun polymer scaffolds for biomedical applications", has been accepted by the University of Manchester for the degree of Doctor of Philosophy. This completes the Neotherix-supported EPSRC CASE project supervised by Professor Sandra Downes at the School of Materials Science.

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04/06/14 Applicants sought for UEA CASE PhD studentship with Neotherix

Tissue engineering and regenerative medicine (TERM) seeks to restore, maintain or improve tissue or organ function. This can be either by stimulating the body's own repair mechanisms or by replacing with functional tissue grown ex vivo. Innovative biomaterial-based technologies are required in order to realise the potential of TERM. Despite intensive research into preparation of scaffold materials, there are still pressing needs to develop innovative functional scaffolds to meet the challenges of new therapies.

Talented candidates with a background in biomaterials, tissue engineering and cell biology are now being sought for a 3.5 year PhD studentship with the University of East Anglia, developing novel biomaterials for musculoskeletal and orthopaedic applications. It is sponsored by Neotherix and EPSRC through an Industrial CASE award, and takes advantage of the combined expertise of Neotherix and the School of Pharmacy at the University of East Anglia.

The successful candidate will be supervised Dr Aram Saeed (School of Pharmacy, University of East Anglia), clinical supervisor Prof Simon Donell (Norfolk and Norwich University Hospital, Norwich) and industrial supervisor Dr Mike Raxworthy (Neotherix Limited, York).

The deadline for applications, which must be made through the University of East Anglia's postgraduate applications web page Link to external web site, is 6 July 2014.

See the project's web page Link to external web site or Dr Aram Saeed's profile Link to external web site for more information. Enquiries regarding this opportunity should be made to Dr Aram Saeed at aram.saeed@uea.ac.uk in the first instance.

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02/05/14 Key patent granted in Japan

A key patent protecting Neotherix' bioresorbable tissue regeneration scaffold technology has recently been granted in Japan. Japanese patent JP 5436205 was issued on 5 March 2014 and is licensed to Neotherix by Smith & Nephew PLC for a wide range of soft tissue repair, dental and surgical applications.

The patent describes scaffolds (including those made by electrospinning) that can be used as medical devices for guided tissue regeneration and repair, in particular bioresorbable scaffolds where the fibre diameter has been optimised for colonisation by cells involved in wound repair. This brings the total number of granted patents in this family to four: South Africa (ZA 200809489), United States (US 8338402), Australia (AU 2007251370) and Japan. Applications are still being pursued in other regions including Europe.

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30/04/14 Presentations from Nano4Life event now available

Presentations from the Nano4Life event on 5 March 2014 are now available for download on the Nano KTN web site. Regenerative Electrospun Scaffolds for Soft Tissue Repair, presented on the day by Neotherix CEO Dr Mike Raxworthy, provides an overview of our project portfolio including the acute and chronic wound therapies due to reach first-in-man clinical investigation within the next year.

Download these presentations from the NanoKTN web site Link to external web site (in order to download these presentations you must be registered with the TSB _connect site and join the Nano KTN network, which is free).

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14/03/14 Case study published on collaborative project between Neotherix and the University of Manchester

A case study describing an ongoing collaborative project between the University of Manchester and Neotherix has been published on the Regener8 web site. The 12 month project, “Polymeric scaffolds functionalised for periodontal repair”, started in October 2013. It is supported by funding from the Regener8-Medical Technologies Innovation and Knowledge Centre (IKC) strategic partnership and is one of the proof of concept awards made to N8 university-based projects that demonstrate significant commercial potential. The case study describes how the interdisciplinary team is developing an implantable acellular electrospun barrier scaffold to help reduce the bone loss and tooth loosening associated with advanced periodontal disease. The bioresorbable scaffold will provide a barrier layer between diseased gum and the mandibular bone, promote new bone growth, and then degrade into harmless by-products once it has completed its function. Benefits of this approach include the provision of a simpler, more effective treatment without the need for multiple surgeries.

Neotherix is contributing its experience in scaling up and commercialising electrospun tissue scaffolds to help demonstrate the clinical and commercial opportunities for this technology.

Please see the Regener8 case study Link to external web site for more information on the project.

Link to the Medical Technologies IKC web site Link to external web site.

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05/03/14 Neotherix presenting at Nano4Life 6th Annual Conference and Exhibition

Neotherix CEO Dr Mike Raxworthy will be speaking later today, 5 March 2014, at the Nano4Life 6th Annual Conference and Exhibition in London. The conference provides a forum for the exchange of ideas and identification of gaps in the supply chain, and will focus on the convergence of nanotechnology and life sciences. It includes perspectives from clinicians, industry and academics that work with and develop nanotechnologies for the healthcare sector.

Mike's presentation, Regenerative Electrospun Scaffolds for Soft Tissue Repair, will focus mainly on our acute and chronic wound therapies due to reach first-in-man clinical investigation within the next year. The presentation will also cover more recent applications of this technology involving the encapsulation of agents within electrospun scaffold fibres and the functionalisation of scaffolds.

Please see the Nano4Life event flyer Link to external web site for more information.

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26/02/14 Neotherix attending Nanofibres to Nanocomposites III conference

Neotherix will be attending the third Nanofibres to Nanocomposites conference, to be held on Thursday 27 February 2014 at Medicity in Nottingham. The one day event, which follows on from the previous event held at Nottingham Trent University in October 2012, will provide further insight into the production and applications of nanofibre-based materials.

Please see the Nanofibres to Nanocomposites III event flyer Link to external web site for more information.

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27/01/14 Neotherix attending 2014 BioSynergy Conference

Neotherix CEO Dr Mike Raxworthy will be attending the 2014 BioSynergy Conference, to be held on Wednesday 29 January at the Food and Environment Agency (FERA) in York. The one day event, co-hosted by Science City York and Bionow, will focus on helping the life sciences community connect with potential partners, and will include one-to-one pre-booked networking sessions and themed workshops.

See the BioSynergy event web page Link to external web site for more information.

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21/01/14 Neotherix listed on map of UK Regenerative Medicine landscape

Neotherix has been listed in a searchable map of the UK Regenerative Medicine R&D sector produced by the HealthTech and Medicines KTN (Health KTN).

The map can be used to search the UK Regenerative Medicine landscape by region and/or organisation type.

See the Health KTN map of the UK Regenerative Medicine R&D sector Link to external web site.

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09/01/14 MeDe Innovation Launch and iMBE Annual Conference

Neotherix will be attending the launch of MeDe Innovation, the EPSRC Centre for Innovative Manufacturing in Medical Devices in Leeds on Friday 10 January 2014. The conference will also incorporate the 37th Leeds iMBE Annual Day Conference - Innovative Manufacturing in Medical Devices.

For more information and a programme for the day see the MeDe web site Link to external web site.

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