Researchers at UEA have had a paper published in the European Polymer Journal on the use of polymers made by a novel synthetic route to complex with DNA (polyplexation). Star-shaped PDMAEA polymers were found to perform better in polyplexation than linear polymer variants and to be equally non-cytotoxic at low (10kDa) molar mass. The findings indicate that star-shaped PDMAEA polymers may be effective as non-viral gene delivery vectors.
Authors include Dr Aram Saeed and members of his research group (Xin Liao, Noelia Falcon and Grace Walden - whose PhD studies are supported by an EPSRC ICASE grant for which Mike Raxworthy is the industrial supervisor. Grace's other supervisors Simon Donell and Graham Riley are also authors on the paper.
The article in press is X. Liao et al, A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines; Eur Polym J (2016) .