Dr Lorenzo Pio Serino, Biomaterials Scientist at Neotherix, is a co-author of a paper just published in Materials Science and Engineering C (Materials for Biological Applications). The paper, "Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering" describes collaborative work carried out by Lorenzo Pio while seconded by Neotherix to the University of Nottingham to learn about PLGA hydrogel technology.
The paper describes a new approach to modifying the rate of protein release from poly(DL-lactic acid-co-glycolic acid) (PLGA) microparticles. Blending the PLGA with triblock copolymers of PLGA and poly(ethylene glycol) (PEG) allowed the rate of release of a model protein, lysozyme, to be 'pre-programmed' or pre-selected. This approach could be used to create microparticle-based tissue engineering constructs with pre-programmed release properties. Neotherix are now applying some of the broad concepts explored during this secondment to their i4i-funded RegeniTherix project.
Please see Qodratnama, R, Serino, LP, Cox, HC, Qutachi, O and White, LJ Materials Science and Engineering C 2015, 47:230-236 for more information.